Grey Hair is the Result of DNA Damage

Credit: Ken Inomata/Kanazawa University
It seems that some Japanese researchers have figured out that genotoxic stress can cause hair follicles to go white, as it were. But it’s not that the stress actually causes the lack of pigmentation, but rather that the stress causes the cells to use up their pigmentation faster than they should, and once the pigment runs out, it’s silver city, baby.
Some years ago, a dermotologist in Japan, Emi Nishimura, discovered that hair follicles are filled with melanocyte stem cells. If you look at the base of that word, melan-, you may associate it with melanin, which gives animals and plants pigment. The melanocyte stem cells hang out in your hair follicle and whenever a new hair starts to grow, some of those stem cells become the melanocytes, or the cells responsible for your hair’s color. Some of the stem cells stay behind, so to speak, waiting for the next strand to come along. Ideally, your body should store enough of these little dabs of color to last your lifetime, but new research shows that stress to the DNA in the cells cause more of the melanocytes to join whatever hair is growing, leaving fewer and fewer color cells behind for the next hair.
Nishimura suspected that genotoxic stressors, such as radiation or harsh chemicals, might play a role in the stem cells’ fate, because they’ve been implicated in other signs of aging. She and colleagues at Japan’s Kanazawa University tested the idea in mice, which also gray with age. After exposure to cell-stressing x-rays or chemotherapy drugs, young mice went gray in an unexpected way. More of their melanocyte stem cells matured into color-producing melanocytes, depleting the store of stem cells. Instead of dying or being inactivated, the DNA-damaged cells matured before their time.
“The mature cells lose their regeneration capabilities,” Nishimura explains. “The mice then can’t produce enough pigment-making cells” and consequently go gray. Moreover, the stressed mice’s gray hairs and the cell populations in their follicles were indistinguishable from those of elderly mice, suggesting that genotoxic stress might drive natural graying as well. –ScienceNOW Daily News
So basically, genotoxic stress — that is anything from ultraviolet light to the natural division of the cell itself — damages your cells’ DNA, but it also leads to the “maturing” as it were. If the cell is mature, it is no longer dividing like cells do. If a cell is not dividing, it’s not reproducing itself. Is this early maturation process a defensive move on the part of damaged cells that shut down their reproductive processes in order to not pass on the damage (DNA defect) to its “children”?
Although, truth be told, I’m sure that this research will be used to prevent grey hair, rather than to prevent cancer. Hey, I’m a cynic.
cells, stem cells, grey hair, gray hair, going grey, DNA, cancer, cell division, cell maturation, melanocyte stem cells, Kanazawa University, Emi Nishimura, mice


And yes, our dear friends DDT, an overly effective pesticide that has been banned around the world, but doesn’t seem to want to go away; PBDEs, or flame retardants which are only know being scrutinzed despite their ubiquity; and PCBs, again a banned chemical family that just doesn’t go away have all been found in the marine mammalian brain studied by Montie. In fact, the levels of PCBs in the seal were in the parts per million, which may seem small, but according to Montie, “you rarely find parts per million levels of anything in the brain.”
So what’s the big deal? Well, PCBs kind of trick a body into thinking that they are thyroid hormones and instead of healthy and needed thyroid hormones, the body gets PCBs. That can lead to all sorts of neurological issues and problems when it comes to brain development and can disrupt the sensory functions of mammals like dolphins, seals and whales that really depend on their sense of hearing to live.
Maybe you are aware that the US Congress is finally attempting to address anthropogenic climate change, and by that I mean to say that the US government is maybe poised to possibly pass legislation in support of not only lowering carbon emissions, but also promoting renewable and clean energy sources.
Now, whether you blame human activity for global climate change issues or not, this move toward clean, renewable energy is smart and forward-thinking. Oil, gas and coal will run out one day. Why not do some planning now to make the transition easier for everyone when that time comes? Not only that, but fossil fuels almost invariably result in some form of waste that pollutes our land, air and water. I’ve never heard of a wind turbine leaching heavy metals into the groundwater supply.
Will the Chicago BPA ban end up repealed like the Chicago Fois Gras ban? Well, fois won’t kill you, and maybe neither will BPA. But — and maybe I am crazy in thinking this — if there is a chance of this chemical leaching from our sippy-cups into the high-fructose corn syrup-laden juices we feed our kids, then shouldn’t we err on the side of caution? There is no real need to produce plastics that contain BPA, so why are we clinging to them like our guns and religion?
As if
Methyl isocyanate is not the only chemical that Bayer can use to produce carbaryl, but it is the cheapest. So you see, it’s not that Bayer has to use MIC, it’s that it is more profitable to use MIC. And we all know that profits come before human health and safety.
Everyone except Bayer, that is. And then, last year, an explosion at a Bayer CropScience plant in Institute, West Virginia narrowly avoided another disaster. The fire at the plant was a mere 80 feet from the above-ground MIC storage tank. At the time, 
However, Entergy has not done much to expand its renewable power portfolio. And one form of the cap and trade law could include a government mandate as to how much renewable energy a company has to produce. That would make Leonard sad. He doesn’t think the Fed should mandate this renewable component, as he feels that the free market will prevail in encouraging companies to invest in the most economical renewables (if there are any in Leonard’s eyes) in order to decrease costs for pollution permits.
So, this insight into how one energy company views the current debate over cap and trade legislation is interesting to me, but also rather irritating. Think about it. Entergy is but one of many, many large and rich corporations that produce energy and do in it a way that pollutes the Earth. Each company is going to do its best to pressure someone in Congress to adjust, rewrite or add an amendment to the cap and trade law, if it even passes, that will be advantageous to that company, perhaps to the detriment to another company, who will then fight the new law. I just don’t see cap and trade passing any time soon, but then again,
Scientists in Spain may have made a bee-line in the fight to save the honeybees. One possible reason for the devastating Colony Collapse Disorder is a really, really small parasite called Nosema ceranae. It is not totally agreed on in the scientific community what indeed has or is causing CCD in the honeybee populations in Europe and the US, but more data and more testing is showing evidence of an Asian parasite-strain, the Nosema ceranae, jumped from the Apis cerana, or the Asian Honeybee, to Apis mellifera, otherwise known as the Western Honeybee.
As a life-long night owl that continues to try and switch her clock around to join the rest of the world on that early morning commute to school, work, or whatever it is we humans do early in the morning, I have to say it’s difficult for me. I find that when I do change my sleep schedule, and start rising at say 8 or 9 in the morning, but the time it rolls around to 11pm, I am falling asleep in my chair. Nothing stops it — caffeine, sugar, slaps to the face.
Could this be the evidence I need to insist that I really do need to sleep in until 11am?
What I don’t get is this fanatical need for the US Energy Kings to push the “grow the economy” paradigm. Maybe our economy is built on the same inflated values of Wall Street. It’s like we just found this cheap energy trough, and like pigs, we are stuffing ourselves with no thought to the consequences (like why is the farmer fattening us up in the first place?).
First, let me begin by saying that yes, I do believe that anthropogenic activity is creating a dangerous imbalance in carbon dioxide and other greenhouse gases in our atmosphere. But do I think that everything can be chalked up to global warming or that we are all going to die from global warming, then the answer is no.
Ok, I’m going out on a limb here. Let’s say that yes, the Sun is going into a cooling period and we can buy some time before the full effects of the Carbon Crisis are felt. That might just be our only chance to ensure that we can curb our reliance on living fat of the oily and gaseous land, and start reversing some of the damage we have inflicted on our closed-ecosystem. Global warming may be held off, but for how long? For every Minimum, there is a Maximum. And if when that next Maximum hits, will we be worse off due to inaction and inertia, or could we be ready for it?
My only fear with these AI “sci-lons” is what will happen when they figure out the only way to solve the climate crisis, the food crisis, the extinction crisis, the water crisis, etc would be to kill all humans?

I’m going to play armchair scientist and offer a theory. This white-nose syndrome is a
A test run of a new software suite called INSTEDD in Southeast Asia holds a world of promise when it comes to coordinating information across multiple users and agencies, locations, database configurations. Think of it as social networking among emergency and crisis workers and the people locally by anything from
The INSTEDD suite consists of GeoChat, which “
To determine a safe amount…This is what I’ve been waiting for, people. I am curious as to how much more carbon dioxide and CFCs and nitrous oxide can be allowed before we hit a tipping point. Not trying to be a Negative Nelly today, but we really need to take a sober look at the state of our planet.